A eficácia de mirtazapina foi comprovada nos seguintes estudos:
“Mirtazapine: a review of its use in major depression and other psychiatric disorders.” (Croom, K.F. and Plosker, G. L. 2009); “Effectiveness of mirtazapine in the treatment of depression with associated somatic symptoms.” (García, C. J. 2008); “Mirtazapine: a review of its clinical efficacy and tolerability.” (Szegedi, A. and Schwertfeger, N. 2005); “Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache.” (Bendtsen, L. and Jensen, R. 2004); “Mirtazapine in the treatment of mood and anxiety disorders.” (Ostacher, M. J., Eisner,
L.and Nierenberg, A. A. 2003).