A eficácia terapêutica da fluvoxamina no tratamento da depressão foi claramente estabelecida em estudos clínicos controlados com placebo1,2, antidepressivos tricíclicos3-8, inibidores seletivos da recaptação da serotonina (ISRS) como a paroxetina9,10, fluoxetina11, sertralina12,13 e citalopram14 e com inibidor da recaptação da serotonina e da noradrenalina, como a venlafaxina15.
Além disso, também foi demonstrada a eficácia terapêutica de fluvoxamina no tratamento da depressão associada à ansiedade 16,17,18, da depressão recorrente19 e da depressão psicótica20,21. A eficácia terapêutica da fluvoxamina no tratamento do transtorno obsessivo compulsivo foi demonstrada em estudos clínicos controlados com o placebo22,23, com a clomipramina24,25,26 e com paroxetina e citalopram27.
A eficácia terapêutica da fluvoxamina em estudo clínico aberto28 e estudos clínicos controlados com placebo29,30.
Referências bibliográficas
1.PORRO, V.; FIORENZONI, S.; MENGA, C. et al. Single-blind comparison of the efficacy of fluvoxamine versus placebo in patients with depressive syndrome. Current Therapeutic Research , 1988. v. 43, p. 621-629.
2.CONTI, L ; DELL’OSSO, L ; RE, F. et al Fluvoxamine maleate: double-blind clinical trial versus placebo in hospitalized depressed-patients. Current Therapeutic Research. 1988. v. 43, p. 468-480.
3.GUELFI, J.D.; FREYFUS, I. F.; PICHOT et al. Fluvoxamine and imipramine: results of a long-term controlled trial. International Clinical Psychopharmacology. 1987. v. 2, p. 103-109.
4.FEIGHNER, J.; BOYER, W.; MEREDITH, C. H.; et al. A placebo-controlled in patient comparison of fluvoxamine maleate and imipramine in major depression. International Clinical Psychopharmacology. 1989. v. 4, p. 239-244.
5.OTTEVANGER, E.A. Fluvoxamine and clomipramine in severely depressed hospitalized patients: a randomized, double-blind study. L’Encephale. 1995.v. 21, p. 317-321.
6.GUELFI, J.D.; SUTET, P. Long-term study of fluvoxamine versus clomipramine.Clinical Neuropharmacology. 1992. v. 15 (Suppl 1), p. 331B.
7.HARRIS, B.; SZULECKA, T.K.; ANSTEE, J. A. Fluvoxamine versus amitriptyline in depressed hospital out-patients: a multicentre double-blind comparative trial. British Journal of Clinical Research. 1991. v. 2, p. 89-99.
8.REMICK, R. A.; REESAL, R.; OAKANDER, M. et al. Comparison of fluvoxamine and amitriptyline in depressed outpatients. Current Therapeutic Research. 1994. v. 55, p. 243-250.
9.ANSSEAU, M.; GABRIELS. A.; LOYENS, J. et al. Controlled comparison of paroxetine and fluvoxamine in major depression. Human Psychopharmacology. 1994. v. 9, p.329-336.
10.KIEV, A.; FEIGER, A. A double-blind comparison of fluvoxamine and paroxetine in the treatment of depressed outpatients. Journal of Clinical Psychiatry. 1997. v. 58, p. 146-152.
11.RAPAPORT, M.; COCCARO, E.; SHELINE, Y. et al. A comparison of fluvoxamine and fluoxetine in the treatment of major depression. Journal of Clinical Psychopharmacology.1996. v. 16, p. 373-378.
12.NEMEROFF, C. B.; NINAN, P. T.; BALLENGER, J. C. et al. Double-blind multicenter comparison of fluvoxamine versus sertraline in the treatment of depressed outpatients.Depression. 1995. v. 3, p. 163-169.
13.FRANCHINI, L.; GASPERINI, M.; PEREZ, J. et al . A double-blind study of long-termtreatment with sertraline or fluvoxamine for prevention of highly recurrent unipolar depression. Journal of Clinical Psychiatry .1997. v. 58, p. 104-107.
14.HAFFMANS, P. M.; TIMMERMAN, L.; HOOGDUIN, C. A. et al. Efficacy and tolerability of citalopram in comparison with fluvoxamine in depressed outpatient: a double blind, multicentre study. International Clinical Psychopharmacology. 1996. v. 11, p. 157-164
15.ZANARDI, R.; FRANCHINI, L.; SERRETI, A. et al. Venlafaxine versus fluvoxamine in the treatment of delusional depression: a pilot double blind controlled study. J Clin Psychiatry. 2000. v. 61, p. 26-30.
16.NUTT, D. Management of patients with depression associated with anxiety symptoms. Journal of Clinical Psychiatry. 1997. v. 58 (Suppl 8), p. 11-16.
17.HOUCK, C. An open label pilot study of fluvoxamine for mixed anxiety depression.
Psychophamacology Bulletin. 1998. v. 34, p. 225-227.
18.LAWS, D.; ASHORD, J. J.; ANSTEE, J. A. A multicentre double blind comparative trial of fluvoxamine versus lorazepam in mixed ansiety and depression treated in general practice. Acta Psychiatrica Scandinavia. 1990. v. 81, p. 185-189.
19.TERRA, J. L.; MONTGOMERY, S. A. Fluvoxamine prevents recurrence of depression: Results of a long-term, double-blind, placebo-controlled study. International Clinical Psychopharmacology. 1998. v. 13, p. 55-62.
20.GATTI, F.; BELLINI, L.; GASPERINI, M. et al. Fluvoxamine alone in the treatment of delusional depression. American Journal of Psychiatry. 1996. v. 153, p. 414-416.
21.ZANARDI, R.; FRANCHINI, L.; GASPEINI, M. et al. Long term treatment of psychotic delusional depression with fluvoxamine an open pilot study. International Clinical Psychopharmacology. 1997. v. 12, p. 195-197.
22. GREIST, J. H.; JENIKE, M. A.; ROBINSON, D.; et al. A. Efficacy of fluvoxamine inobsessive-compulsive disorder: results of a multicentre, double-blind, placebo-controlled trial. European Journal of Clinical Research. 1995.v. 7, p.195-204.
23. GOODMAN, W. K.; KOZAK, M. J.; LIEBOWITZ, M.; et al. Treatment of obsessive compulsive disorder with fluvoxamine: a multicentre double blind placebo controlled trial. International Clinical Psychopharmacology. 1996. v. 11, p. 21-29.
24.KORAN, L. M.; MCELROY, S. L.; DAVIDSON, J. R. T. et al. Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison. Journal of Clinical Psychopharmacology. 1996. v. 16, p. 121-129.
25.MILANFRANCHI, A.; RAVAGLI, S.; LENSI, P. et al. A double-blind study of fluvoxamine and clomipramine in the treatment of obsessive-compulsive disorder. International Clinical Psychopharmacology. 1997. v. 12, p. 131-136.
26.MUNDO, E.; ROUILLON, F.; FIGUERA, M. L. et al. Fluvoxamine in obsessive- compulsive disorder: similar efficacy but superior tolerability in comparison with clomipramine. Journal of Clinical Psychopharmacology, submitted.
27.MUNDO, E.; BIANCHI. L.; BELLODI, L. Efficacy of fluvoxamine, paroxetine, and citalopram in the treatment of obsessive-compulsive disorder: a single-blind study. Journal of Clinical Psychopharmacology. 1997 v. 17(4), p. 267-271.
28.APTER, A.; RATZONI, G.; KING, R.A.; et al. Fluvoxamine open-label treatment of adolescent in patients with obsessive-compulsive disorder or depression. J Am Acad Child Adolesc Psychiatry, 1994; v 33, p 342-348.
29.RIDDLE, M. Obsessive compulsive disorder in chidren and adolescents. British Journal of Psychiatry, 1988; 35 (Suppl), p 91-96.
30.RIDDLE, M.A.; REEVE, E. A.; YARYURA, J. A.; et al. Fluvoxamine for children and adolescents with obsessive-compulsive disorder: a randomized, controlled, multicenter trial. J Am Acad Child Adolesc Psychiatry, 2001; 40(2), p 222-229.
Resultados de eficácia luvox
LUVOX com posologia, indicações, efeitos colaterais, interações e outras informações. Todas as informações contidas na bula de LUVOX têm a intenção de informar e educar, não pretendendo, de forma alguma, substituir as orientações de um profissional médico ou servir como recomendação para qualquer tipo de tratamento. Decisões relacionadas a tratamento de pacientes com LUVOX devem ser tomadas por profissionais autorizados, considerando as características de cada paciente.