Eficácia de metronidazol foi demonstrada nos seguintes estudos: ”Metronidazole – A therapeutic Review and Update.” (FREEMAN, C. D 1997); “Prevention of postcesaren infectiouos morbidity with a single dose of intravenous metronidazole. (RUIZ-MORENO, J.A. 1991); “Efficacy of intravaginal 0,75% metronidazole gel for the treatment of bacterial vaginosis.” (HILLER, S.H. 1993); “Comparation of oral and vaginal metronidazole therapy for nospecific bacterial vaginosis”. Gynecol.“ (BISTOLETTI, P. 1986); “Estudio multicêntrico nacional metronidazol-nistatin em infecciones vaginales mixtas (tricomona + Cândida).” (Somera, J. 1987).