Antak® proporcionou cura da úlcera duodenal em 83% dos pacientes, comparada com 32% do grupo placebo, após 4 semanas de tratamento. Pacientes com úlcera gástrica tratados por 12 semanas alcançaram a cura em 89% dos casos, comparada com 72% do grupo placebo.Taxas de cura para esofagite erosiva foram 83 e 81%, respectivamente, para os grupos que usaram 150 e 300 mg de ranitidina (grupo placebo = 58%).
JOHNSON, JA; et al. Ranitidine 300 mg at bedtime is effective for gastric ulcers: a 12-wk, multicenter, randomized, double- blind, placebo-controlled comparison. The Ranitidine 300 mg HS Gastric Ulcer Study Group. Am J Gastroenterol. [S.l.], v. 88, n. 7, p. 1071-75, 1993.
ROUFAIL, W; et al. A study of two hundred and eight patients in premature labour treated with orally administered Ranitidine for erosive oesophagitis: a double-blind, placebo-controlled study. Glaxo Erosive Esophagitis Study Group. Aliment Pharmacol Ther. [S.l.], v. 6, n. 5, p. 597-607, 1992.
LEE, FI. Comparison of twice-daily ranitidine and placebo in the treatment of duodenal ulcer – a multicentre study in the United Kingdom. [S.l.], v. 29, n. 3, p. 127-129, 1982.